Comprehensive one-day renal function testing in man

A one-week introductory course in clinical biochemistry and research based on renal function testing in man.

A one-week introductory course in clinical biochemical and research techniques was devised to provide a brief but concentrated experience for interested persons. Urinary creatinine concentrations were measured to demonstrate acceptable degrees of precision of a method (co-efficients of variation, 0.5-2.4%), and to give confidence by favourable comparison with routine laboratory results (day 2, ...

Diurnal variations of renal function in man.

A diurnal rhythm in water and electrolyte excretion in man has been described by several investigators. Kleitman (1) reported decreased urine flow and chloride excretion during sleep as compared to "waking" hours, and suggested decreased blood pressure during sleep as the cause. Simpson (2, 3) confirmed these observations in young healthy adults who ingested the same amount of water at hourly i...

Renal function during chronic anemia in man.

P HYSIOLOGICAL adjustments to slowly developing anemia are so successful that anemic patients characteristically present themselves with only minor complaints of fatigability, weakness, or dizziness, despite severe reductions of the hematocrit to i per cent orless. These adjustments are largely cardiovascular.’ Oxygen transport is maintained by a marked augmentation of blood flow through most p...

ORE CURRICULUM IN NEPHROLOGY Renal Function Testing

● Patients with kidney disease have few signs and symptoms early in disease course; laboratory evaluation may be only way of detecting disease ● Tests should detect abnormalities early enough to allow corrective therapy ● Important for measuring renal disease progression and efficacy of therapies ● Help predict when renal replacement therapy may be necessary ● Aid in appropriate dosing of medic...

Human organs-on-chips may one day replace animal testing